A 50-amp circuit needs 6 AWG copper or 4 AWG aluminum. The math: 50 A × 1.25 (continuous rule) = 62.5 A required ampacity. At the 75°C column of NEC Table 310.16, 6 AWG copper carries 65 A — the smallest size that clears 62.5 A. Aluminum steps up to 4 AWG (65 A).
That covers most 50-amp uses: electric ranges, hot tubs and spas, welders, RV pedestals, and 50 A EV chargers. But run length matters. On circuits longer than roughly 100–150 feet, voltage drop can push the recommendation to 4 AWG copper even though 6 AWG passes ampacity. The calculator above checks both so you get the right answer for your specific run.
One point of confusion worth clearing up immediately: the "50" in a 50-amp circuit refers to the breaker rating, not the wire's ampacity. Because 8 AWG copper happens to be rated 50 A at 75°C, people assume it is the "50-amp wire." It is not — the continuous-load rule requires the conductor to have ampacity of 62.5 A, which lands on 6 AWG. Reserve 8 AWG for 40-amp circuits, and treat 6 AWG copper (or 4 AWG aluminum) as the default 50-amp conductor unless a long run or heavy derating calls for more.